There has been tremendous progress in the past few years regarding our understanding of DNA replication in eukaryotes, both yeast and mammals. Many important questions in the field are poised to be ...

The dire consequences of a poor response to replication stress are clinically apparent in genetically inherited premature aging disorders 3. A common feature of these diseases is chromosomal ...

A new discovery by researchers at the RIKEN Center for Biosystems Dynamics (BDR) in Japan upends decades of assumptions regarding DNA replication. Led by Ichiro Hiratani and colleagues, the ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

DNA interstrand crosslinks (ICLs) are toxic lesions that block DNA replication and transcription, and are detected and repaired by the Fanconi anaemia pathway. The FANCD2–FANCI (D2–I) complex is key ...

DNA replication is happening continuously throughout the body, as many as trillions of times per day. Whenever a cell divides—whether to repair damaged tissue, replace old cells, or simply to help the ...