Researchers at the University of Illinois Urbana-Champaign have built a computer simulation that tracks the entire life cycle of a living cell in four dimensions, capturing how the genetically minimal ...

Our group investigates the molecular mechanisms of transcriptional regulation of the cyclin genes by the Muv-B complexes, during quiescence and mitosis initiation. The cell cycle is the fundamental ...

Before cells can divide, they first need to replicate all of their chromosomes, so that each of the daughter cells can receive a full set of genetic material. Until now, scientists had believed that ...

Cell division allows a single fertilized egg to develop into a living being, our skin to renew itself, and wounds to heal. Before each cell division, termed mitosis, the genetic information must first ...

A zebrafish embryo during the first cell division cycle, with the structural protein actin labelled, which marks the cell boundary and ingressing furrow. The image shows a time course from dark orange ...

The story of the cell cycle is often told only through the perspective of the chromosomes as they replicate and then divide. This resource beautifully illustrates the role of the cytoskeleton in that ...

A metabolic enzyme also binds and unwinds RNA to promote translation of cell cycle genes. This dual role links energy status to cell division, revealing a molecular switch that controls growth, and ...

Arteriovenous malformations, a hallmark of hereditary hemorrhagic telangiectasia, may be driven by endothelial cell-cycle acceleration via CDK6, suggesting potential for repurposing CDK6 inhibitors.

Before a cell can divide, it has to precisely duplicate its entire genetic information. However, the DNA in the cell exists as part of a DNA-protein complex known as chromatin. For this purpose, the ...