Knowledge of the frequencies of synonymous triplets in protein-coding and non-coding DNA stretches can be used in gene finding. These frequencies depend on the GC content of the genome or parts of it.

A key characteristic of cancer cells is their increased proliferative capacity, which requires elevated levels of protein synthesis. The process of protein synthesis involves the translation of codons ...

We demonstrate the use of the Chlamydomonas chloroplast genome as a synthetic biology platform to test radical compression of the universal genetic code. Genome engineering was used to generate ...

We present an evolutionary hypothesis assuming that signals marking nucleotide synthesis (DNA replication and RNA transcription) evolved from multi- to unidimensional structures, and were carried over ...

This is a simple Python CLI tool to reduce the G/C count in a sequence of RNA while still retaining the same amino acids. By default, the optimizer will look to 80% reduce G/C and 20% to use common ...

This is a simple Python CLI tool to reduce the G/C count in a sequence of RNA while still retaining the same amino acids. By default, the optimizer will look to 80% reduce G/C and 20% to use common ...

Here is an impressive example of the utility of neighbor-aware codon optimization: no soluble protein using traditional optimization, good yield with Proteolutions.