Consistent with an anticancer function for complement and a countermeasure to its action, tumors often have higher expression of complement-regulatory proteins such as CD46, CD55 and CD59. These ...

The complement system is a diverse set of proteins long known for its association with innate immunity. Recent decades have demonstrated novel location and roles for key complement proteins in the ...

In antibody-mediated allograft rejection, donor-reactive antibodies cause transplant injury in part via complement activation. New mechanistic insights indicate complement also modulates development ...

The complement system is considered to be an important part of innate immune system with a significant role in inflammation processes. The activation can occur through classical, alternative, or ...

The complement system is a recognized pillar of host defence against infection and noxious self-derived antigens. Complement is traditionally known as a serum-effective system, whereby the liver ...

We thank Paul N. Barlow for providing the fH(19–20) protein. This study was supported by National Institutes of Health Grants AI030040, AI068730, AI072106, GM062134, AI071028, CA099835, CA118595, ...

Complement molecules are the immune proteins responsible for identifying bacteria, viruses, and other foreign invaders as they circulate through our bodies. Their function helps lymphocytes to locate ...

Traumatic brain injury (TBI) is a major cause of disability and a risk factor for early-onset dementia. The injury is characterized by a physical insult followed acutely by complement driven ...

PHOENIX, Arizona—Nipocalimab might lower the concentration of anti-acetylcholine receptor antibodies, or anti-AChR antibodies, in people with generalized myasthenia gravis, reducing neuromuscular ...

Background Anti-C1q autoantibodies can disrupt normal complement function, contributing to the formation of pathogenic immune complexes and end-organ damage. Although their role in SLE is ...