For the complement system to cause AMD, there must be initiation (a ‘trigger’), amplification, and local retinal damage caused by the process. The alternative pathway of the complement system is ...

The complement system is a diverse set of proteins long known for its association with innate immunity. Recent decades have demonstrated novel location and roles for key complement proteins in the ...

Cancer cells are more resistant to complement-mediated lysis and use this attribute to set up a locally immunosuppressive environment. However, new findings suggest that tumor-driven complement ...