Over the past two decades it has become clear that the complement cascade — best known for its roles in innate immunity and in the clearance of pathogens and immune complexes — has distinct functions ...

Background B cell complement receptor 1 (CR1) and complement receptor 2 (CR2) levels are decreased by ∼50% in subjects with systemic lupus erythematosus (SLE). CR2 but not CR1 levels have been ...

2 University of Padua, Internal Medicine Unit, Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, Padua, Italy 3 University of Padua, Rheumatology Unit, Department of Medicine, Padua 4 ...

In patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) who are suspected of having an infection, T lymphocyte subsets and immunoglobulin (Ig) and complement levels can ...

1 Ishikawa Natural Medicinal Products Research Center, Ishikawa, Japan. 2 Department of Rehabilitation, Kanazawa Medical University, Uchinada-machi, Japan. 3 Department of General Medicine, Kanazawa ...

Interesting in Cell: Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution https://lnkd.in/ePkzhGPQ Although subsets with immunosuppressive properties exist, ...