Gene copy number variation (CNV) refers to the presence of multiple copies of a gene family within a genome resulting from duplications, deletions, or rearrangements. In general, CNV may result from ...
Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver mutations
Cancer driver genes can undergo positive selection for various types of genetic alterations, including gain-of-function or loss-of-function mutations and copy number alterations (CNA). We investigated ...
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