Relapse to drug abuse is often caused by exposure to drug-associated cues that evoke craving. Therefore, disruption of the cue–drug memory can prevent relapse. Memories destabilize and become ...

The evidence for the effectiveness of counterconditioning as a strategy for changing conditioned preferences is rather scarce and inconclusive. The present experiment reinvestigated this issue and ...

For example, having the light followed by shock on a randomly selected 25% of trials during the counterconditioning treatment may have made it more difficult for rats to learn that the light was no ...

Version of Record: This is the final version of the article. The authors attempted to replicate previous work showing that counterconditioning leads to more persistent reduction of threat responses, ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

For example, imagine if every time your dog saw a person walk by the house, they lunged at the window, growled, barked, and scratched up your windowsill. These negative feelings and unwanted behaviors ...