NLRP3-mediated inflammation is closely related to the pathological progression of diabetic nephropathy (DN). DsbA-L, an antioxidant enzyme, plays a protective role in a variety of diseases by ...

The synthesis and secretion of adiponectin. Adiponectin has a collagenous tail and a globular head that fold with the help of BiP. The head domains of 3 monomers interact with each other and form ...

The Dsb family of enzymes catalyzes disulfide bond formation in the gram-negative periplasm, which is required for folding and assembly of many secreted proteins. Pertussis toxin is arguably the most ...

Export of DsbA, a protein disulfide bond-introducing enzyme, across the Escherichia coli cytoplasmic membrane was studied with special reference to the effects of various mutations affecting ...

構造解析の結果、単独での酸化力がDsbAより遙かに弱いはずのDsbBがDsbAを酸化する機構が示唆されました。DsbAとの複合体においては、DsbBのペリプラズム領域がDsbAによって捕捉され、そこに含まれるCys104とCys130のペアは互いに引き離され、Cys130はCys41-Cys44ペア ...