While it was once believed that genes regulated biological functions almost exclusively by being transcribed to coding RNAs that were then translated into proteins, it is now known that the picture is ...

Annotating functional elements in the human genome is a major goal in human genetics. Despite years of efforts from both experimental and computational scientists, functional annotation remains ...

Determining the functional consequences of genetic variants is a difficult problem in human genetics. Our understanding of the genetic code and splicing enables us to identify variants that are likely ...

While it was once believed that genes regulated biological functions almost exclusively by being transcribed to coding RNAs that were then translated into proteins, it is now known that the picture is ...

Scientists have generated a comprehensive atlas of human long non-coding RNAs with substantially improved gene models, allowing them to better assess the diversity and functionality of these RNAs.

In RNA molecules, the 5′ untranslated region (UTR) is located directly upstream of the start codon and plays a crucial role in post-transcriptional regulation by controlling RNA stability, cellular ...

Coding variants in immune disease-related genes play only a small part in the overall genetic risk for psoriasis, according to a new study. Coding variants in immune disease-related genes play only a ...