Mendelian randomization is a study design that uses genetic variants as instrumental variables to test the causal effect of a (non-genetic) risk factor on a disease or health-related outcome. Since ...

A major goal of epidemiology is to reduce the burden of disease in populations through interventions that target causal determinants of disease risk. Although observational studies, such as ...

The schematic illustrates the comprehensive pipeline for Mendelian randomization analysis, starting with multi-omics data inputs from GWAS, eQTL, and pQTL studies, sourced from major databases such as ...

ATP citrate lyase is an enzyme in the cholesterol–biosynthesis pathway upstream of 3-hydroxy-3-methylglutaryl–coenzyme A reductase (HMGCR), the target of statins. Whether the genetic inhibition of ATP ...

The comparison of publications/citations in Mendelian randomisation from 2015 to 2024. On the top, it reflects the trend of total publications and citations each year. The keywords in this field are ...