A major goal of epidemiology is to reduce the burden of disease in populations through interventions that target causal determinants of disease risk. Although observational studies, such as ...

Mendelian randomization is a study design that uses genetic variants as instrumental variables to test the causal effect of a (non-genetic) risk factor on a disease or health-related outcome. Since ...

The schematic illustrates the comprehensive pipeline for Mendelian randomization analysis, starting with multi-omics data inputs from GWAS, eQTL, and pQTL studies, sourced from major databases such as ...

The comparison of publications/citations in Mendelian randomisation from 2015 to 2024. On the top, it reflects the trend of total publications and citations each year. The keywords in this field are ...

Mendelian randomization, a powerful tool in medical research, helps us understand whether certain factors truly cause disease. This technique uses genetic variations as "natural experiments" to reveal ...

Introduction to Mendelian randomization, the problems with using traditional observational studies to investigate causality, and Randomized controlled trials as the gold standard for causal research.