For decades, scientists have been puzzled by large portions of the human genome labeled as “junk” DNA, sequences that seemingly serve no purpose. Yet, recent studies suggest these cryptic sequences ...

多くの配列バリアントがヒトの複雑な形質や疾患と関連付けられてきたが、それらの大半はノンコーディングDNA上にあるために、その生物学的機能の解明はいまだに困難である。今回我々は、SNP-SELEX（single-nucleotide polymorphism evaluation by systematic evolution of ligands ...

While it was once believed that genes regulated biological functions almost exclusively by being transcribed to coding RNAs that were then translated into proteins, it is now known that the picture is ...

In RNA molecules, the 5′ untranslated region (UTR) is located directly upstream of the start codon and plays a crucial role in post-transcriptional regulation by controlling RNA stability, cellular ...