Researchers have successfully demonstrated how astroglia—cells that support the functioning of the brain—can be reprogrammed into cells resembling interneurons. The research, published in Science ...

Esketamine, commonly used to treat treatment-resistant depression, has pharmacological mechanisms that remain incompletely understood. Brain organoids offer a human-relevant platform for investigating ...

Resting brain stem cells hardly differ from normal astrocytes, which support the nerve cells in the brain. How can almost identical cells perform such different functions? The key lies in the ...

Human induced pluripotent stem cells (hiPSCs) offer a renewable and scalable source for generating brain endothelial cells (BECs), enabling the development of in vitro blood-brain barrier (BBB) models ...

A mechanism underlying neutrophil reprogramming in brain cancers has been uncovered, illuminating potential therapeutic targets to stop their pro-cancer effect. Tumor-infiltrating neutrophils are ...

Brain metastases are one of the most severe complications of melanoma, the most aggressive type of skin cancer. Researchers at the Institute for Neurosciences (IN), a joint center of the Spanish ...

When a neuron ages, it loses synaptic connections with other neurons, it is less able to transmit nerve impulses, and its metabolism is also altered. This process of neuronal ageing — inevitable with ...

Promising mouse studies and billions of dollars in funding are stoking excitement. But we’ve been here before.