Data-Rich, Insight-Poor? — XLVII: From clustering readouts to structural mechanism Canonical Wnt signaling has long been a textbook example of a data-rich, insight-poor system. The field could measure ...

Mammalian genomes are pervasively transcribed, with tens of thousands of unique loci producing long RNA molecules that do not serve as templates for the production of functional proteins. These RNAs, ...

With the rapid increase in crystal structures of protein-protein complexes deposited in the Protein Data Bank (PDB), more and more crystal contacts have been shown to have similar or even larger ...

Importance of understanding structural principles Structural principles are the foundation upon which every successful construction project stands. It is crucial for architects, engineers, and ...

Abstract: The ultimate goal of systems biology research area is to accurately predict the behavior of biological systems through the construction of computational models, using the related ...