Studying the dynamics of genome replication in mammalian cells has been historically challenging. To reveal the location of replication initiation and termination in the human genome, we developed ...

R-loops have both positive and negative impacts on chromosome functions. To identify toxic R-loops in the human genome, here, we map RNA:DNA hybrids, replication stress markers and DNA double-strand ...

While the lack of FEN1 leads to accumulation of 53BP1, a lack of 53BP1 altogether allows other mechanisms to cleave the long flap and allow DNA repair to reach completion. Tokyo, Japan – Researchers ...