RNA is the means of translating the genetic code embedded in DNA into proteins, which serve as enzymes, transporters, signaling molecules, receptors, structural components, regulators, and ...

RNA splicing is a fundamental biological process that generates diverse transcript isoforms with distinct functions through alternative splicing of precursor mRNA (pre-mRNA), thereby greatly expanding ...

The ability to study transcript isoforms in detail could have a significant impact on our understanding of health and disease. However, most commonly, bulk sequencing is the selected method that only ...

RNA splicing, in which different coding RNA, or exons, are joined together after noncoding regions, or introns, are removed, allows for a large array of RNA transcript isoforms with distinct sequences ...

Researchers uncovered 214,516 unique isoforms in the developing neocortex -- over 70% of which have not been previously studied. A team led by researchers at UCLA and the University of Pennsylvania ...

Long-read platforms that can sequence RNA molecules over 10,000 bases in length end-to-end hold great potential for use in characterizing variations in the ...