Despite the highly conserved nature of the genetic code, the frequency of usage of each codon can vary significantly. The evolution of codon usage is shaped by two main evolutionary forces: mutational ...

This is a simple Python CLI tool to reduce the G/C count in a sequence of RNA while still retaining the same amino acids. By default, the optimizer will look to 80% reduce G/C and 20% to use common ...

We present an evolutionary hypothesis assuming that signals marking nucleotide synthesis (DNA replication and RNA transcription) evolved from multi- to unidimensional structures, and were carried over ...